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There are three Gla proteins in bone: osteocalcin (which also circulates in blood), matrix Gla protein and protein S The precise functions of these three proteins are not clearly established On a normal diet, with normal blood clotting, circulating osteocalcin is not fully carboxylated and substantial supplements are required to achieve 100% carboxylation The clinical signi cance of this under carboxylation is not clear In very elderly women -carboxylation of circulating osteocalcin is impaired and high concentrations of under-carboxylated circulating osteocalcin are associated with low bone density at the hip and increased risk of fracture Low vitamin K intakes in women have been associated with increased risk of hip fracture Women in the lowest quartile of vitamin K intakes have been reported to have lower bone density at the hip and spine than those in the highest quartile of intakes.

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37 Even the most experienced investors can fall into these traps, so what do they do to avoid them Benjamin Graham s discipline of investing with a signi cant margin of safety is a great start The consequences of overestimating a company and your ability to analyze it are greatly diminished when you pay a lot less for it than your analysis shows it is worth Maverick s Ainslie distributes to his analysts every day a Sheet of Shame, which shows the rm s 10 largest losses since original purchase, year-to-date, month-to-date, and for the previous day There are only two ways to get something off the Sheet of Shame which people are eager to do: either eliminate the position or increase the position and be right, earning some of the losses back, he says.

Newborn babies and especially premature babies have low biochemical status for vitamin K and this has been linked to the intracranial haemorrhages that occasionally occur shortly after birth and which may result in death or permanent disability It has thus been common practice to give prophylactic vitamin K to newborn babies (especially premature babies) immediately after delivery to reduce the risk of postnatal brain haemorrhage Earlier concerns that postnatal injections of vitamin K might be associated with an increased risk of childhood cancer now appear to be unfounded (Eklund et al 1993) There is little evidence of natural vitamin K1 toxicity in humans or in experimental animal studies High doses of the synthetic forms do cause adverse effects in animals and humans and have some mutagenic activity in bacteria FSA (2003) considered it.

from tomato products, -carotene from carrots and oranges, -cryptoxanthin from oranges The pinkish colour of salmon and some crustaceans is due to the presence of metabolites of plant carotenoids Some of these carotenoids have vitamin A activity (see 3) Higher terpenoids (more than C40) ubiquinone or coenzyme Q10 (see 7) is a derivative of a higher terpenoid Phenolic compounds (phenols and polyphenols) Phenolic compounds have at least one aromatic ring with at least one hydroxyl (OH) group attached to it More than 8000 phenolic secondary metabolites of plants have been identi ed and they vary from simple molecules with a single aromatic ring to more complex polyphenols which have more than one ring.

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Some of the basic categories of phenols and polyphenols are listed below but there are also polymeric and conjugated forms of these which increases their diversity still further (the basic structures of the phenolic and polyphenolic compounds are shown in Table 81) Phenolic acids are hydroxylated derivatives of benzoic acid and the principal component is gallic acid, so named because it is present in large amounts in plant galls Hydroxycinnamates have one aromatic ring and a three-carbon acidic side chain Stilbenes are polyphenols that have two aromatic rings connected by a two-carbon bridge; they are produced by plants in response to attack by microbial pathogens Flavonoids are polyphenols that have two aromatic rings linked together by a threecarbon bridge a total of 15 carbon atoms.

Another rewriting rule is associated with the LIKE and GLOB operators. This nal rule only applies if the operation of LIKE and GLOB have not been overridden using sqlite3_create_function(). And the rule only applies to LIKE if SQLite is con gured to make LIKE case sensitive using either a compile-time option or